Dr Megan Oliva

BSc (Hons), BEng, BSc (Hons), PhD

Postdoctoral Affiliate

Megan Oliva

College Jobs

  • Postdoctoral Affiliate

University Jobs

  • Post-Doctoral Fellow, Department of Genetics

Contact

Telephone: +44 (0) 7490 275647

Email: megan.oliva@gen.cam.ac.uk

Megan Oliva

Biography

I am originally from Australia where I completed my undergraduate degrees in Biomedical Science and Engineering, and PhD studies in neuroscience. I have recently moved to Cambridge to undertake a post-doctoral position with Cahir O’Kane in the Department of Genetics.

Research Interests

I am interested in the functional consequences of genetic aberration resulting from human diseases. My PhD focused on the functional consequences of epilepsy mutations that effect ion channels in neurons that are key regulators of neuronal excitability, and hence brain activity. My work here at Cambridge is focused on a different neurological disease, hereditary spastic paraplegia (HSP), a neurodegenerative disorder affecting the motor neurons and hence motor movement. My project aims to examine the functional consequences of genetic mutations which have been observed to result in fragmentation of a key cellular organelle, the endoplasmic reticulum, in neurons. To do this I am using fluorescent calcium sensing probes to observe changes in calcium levels in this organelle, which it uses to communicate down its length and also with other components of the cell. I am using the fruit fly as a model system and expressing HSP mutations in them to observe the consequences.